What Is It: A comprehensive review of scientific literature examining the role of glutathione, a critical antioxidant, in the prevention and management of cardiovascular diseases (CVDs), focusing on its mechanisms of action and potential therapeutic applications.

Introduction: Glutathione (GSH) is a vital intracellular antioxidant that plays a central role in maintaining redox balance and protecting cells from oxidative stress. This review delves into the mechanisms by which glutathione influences cardiovascular health, highlighting its significance in detoxifying reactive oxygen species, modulating nitric oxide availability, and maintaining endothelial function. The article emphasizes the correlation between decreased glutathione levels and the progression of various cardiovascular conditions, underscoring the importance of maintaining optimal glutathione concentrations for heart health.

Takeaways: The review underscores the potential of glutathione augmentation as a therapeutic strategy for cardiovascular diseases such as atherosclerosis, hypertension, and ischemia-reperfusion injury. It discusses various approaches to boost glutathione levels, including dietary interventions, supplementation, and pharmacological agents. The article also highlights the challenges associated with glutathione delivery and the need for further research to develop effective methods for enhancing its bioavailability. Overall, maintaining adequate glutathione levels emerges as a promising avenue for promoting cardiovascular health and mitigating disease progression.

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